Cattle encephalon glycoside and ignotin injection promoted synthesis of glial cell line-derived neurotrophic factor by astrocytes that protected against neuronal damage induced by AAPH
نویسندگان
چکیده
Cattle encephalon glycoside and ignotin injection offers neural protection after cerebral apoplexy clinically, but the exact mechanism of the protective effect is unclear. We performed primary culture of neurons and astrocytes and simulated ischemic brain damage using AAPH and discussed the action mechanism of cattle encephalon glycoside and ignotin injection. Results showed that cattle encephalon glycoside and ignotin injection was effective against the neuronal damage induced by AAPH through promoting the secretion of glial cell line-derived neurotrophic factor (GDNF) by the astrocytes.
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